Brune Le Chatelier

The contribution of native protein complexes to targeted protein degradation

This study shows that molecular glue degraders targeting CK1 can co-degrade multiple SACK1 proteins, highlighting the role of protein complex context in targeted protein degradation.

Mutations within the predicted fragment-binding region of FAM83G/SACK1G abolish its interaction with the Ser/Thr kinase CK1α

The paper identifies mutations in SACK1G that disrupt its interaction with CK1α, using computational modeling and experimental validation.

Cortex-wide voltage imaging in a sensory cued reaching task reveals fast subnetwork dynamics

The paper uses voltage imaging to study fast cortical dynamics during a reaching task, identifying distinct oscillatory patterns and network behaviors.

Cortical networks relating to arousal are differentially coupled to neural activity and hemodynamics

The paper examines how arousal correlates with cortical voltage and hemodynamic signals in mice, finding distinct spatial and frequency-dependent patterns.