Nicola T. Wood

This study develops a DIA-based workflow for comprehensive ubiquitinome profiling in targeted protein degradation, identifying over 40,000 ubiquitylated peptides.

This study shows targeted dephosphorylation of phospho-Tau at the endogenous level promotes its association with microtubules.

This study shows that molecular glue degraders targeting CK1 can co-degrade multiple SACK1 proteins, highlighting the role of protein complex context in targeted protein degradation.

This study shows ZNFX1 uses a two-component ubiquitin circuit to trap viral RNA, linking its function to antiviral immunity.

This study identifies HMMR's role in stabilizing the SACK1D-CK1 complex at the mitotic spindle and shows how phosphorylation drives its degradation after mitosis.

The paper identifies a new ALPK1 variant causing ROSAH syndrome and shows it has altered activation by different metabolites, explaining autoinflammatory episodes.