Pervasive noise in human splice site selection
Eraj Shafiq Khokhar, Kaitlyn Brokaw, Zachary J. Kartje, Valeria C. Sanabria, Nida Javeed, Ayush Kumar, Jonathan K. Watts, Athma A. Pai
The paper tracks splicing intermediates in human cells using ultra-deep sequencing and finds pervasive usage of low-fidelity splice sites associated with genomic features that promote splicing noise.
bioRxiv · Jul 16, 2025 · PreprintGenomics