In vivo AAV9-SB-CRISPR screen identifies fatty acid elongase ELOVL5 as a pro-resolving mediator in lung inflammation
Shuo Liu, Jiaming Wang, Liangpo Li, Jun Zhu, Xuetao Cao
Immunity & Inflammation · Nov 4, 2025Peer-reviewedImmunology
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Chinese Academy of Medical Sciences & Peking Union Medical CollegeORCID 0000-0002-4834-967XUnclaimed ORCID profile · follow to get notified of new preprints
2 papers
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Shuo Liu, Jiaming Wang, Liangpo Li, Jun Zhu, Xuetao Cao
Immunity & Inflammation · Nov 4, 2025Peer-reviewedImmunology
Raed Ibraheim, Phillip W.L. Tai, Aamir Mir, Nida Javeed, Jiaming Wang, Tomás Rodríguez, Suk Namkung, Samantha J. Nelson, Eraj Shafiq Khokhar, Esther Mintzer, Stacy A. Maitland, Zexiang Chen, Yueying Cao, Emmanouela Tsagkaraki, Scot A. Wolfe, , Erik J. Sontheimer
This paper develops single-AAV vectors for precise in vivo genome editing using Nme2Cas9 with HDR templates or multiple sgRNAs, showing efficacy in treating HT-I and MPS-I mouse models.
Nature Communications · Nov 1, 2021Peer-reviewedMolecular Biology