Author

Emmanouela Tsagkaraki

The University of SydneyORCID 0000-0001-7754-8945Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Batuhan YenilmeziD· 2 shared Lawrence M. LifshitziD· 2 shared Mark KellyiD· 2 shared Michael CzechiD· 2 shared Naideline RaymondiD· 2 shared Aamir MiriD· 1 shared Adı́lson GuilhermeiD· 1 shared Anastasia KhvorovaiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPhysiology

Batuhan YenilmezORCID

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3 papers

Recent·Most cited

Thermogenic adipocytes alleviate hepatic steatosis and insulin resistance via macrophage cytokine secretion in obese mice

Hui Wang, Mark Kelly, Najihah Aziz, Emmanouela Tsagkaraki, Sarah M. C. Nicoloro, Lawrence M. Lifshitz, Adı́lson Guilherme, Leslie A. Rowland, Batuhan Yenilmez, Kaltinaitis B. Santos, Naideline Raymond, Tiffany DeSouza, Muhammad Tanveer Sajid, Hanna Choi, LAUREN A. TAUER, , Michael Czech

This study shows that adipocyte Nrip1 deficiency in obese mice reduces hepatic steatosis and insulin resistance by promoting M2-like macrophages that secrete IL-1rn.

bioRxiv · Aug 1, 2025 · PreprintPhysiology

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis

Kyounghee Min, Batuhan Yenilmez, Mark Kelly, Dimas Echeverria, Michael Elleby, Lawrence M. Lifshitz, Naideline Raymond, Emmanouela Tsagkaraki, Shauna M. Harney, Chloe DiMarzio, Hui Wang, Nicholas McHugh, Brianna M. Bramato, Brett M. Morrison, Jeffery D. Rothstein, , Michael Czech

This study shows that MCT1 in hepatic stellate cells promotes collagen expression in NASH, while hepatocyte MCT1 does not significantly affect fibrosis.

eLife · Aug 31, 2023Peer-reviewedMolecular Biology

Precision Cas9 Genome Editing in vivo with All-in-one, Self-targeting AAV Vectors

Raed Ibraheim, Phillip W.L. Tai, Aamir Mir, Nida Javeed, Jiaming Wang, Tomás Rodríguez, Suk Namkung, Samantha J. Nelson, Eraj Shafiq Khokhar, Esther Mintzer, Stacy A. Maitland, Zexiang Chen, Yueying Cao, Emmanouela Tsagkaraki, Scot A. Wolfe, , Erik J. Sontheimer

This paper develops single-AAV vectors for precise in vivo genome editing using Nme2Cas9 with HDR templates or multiple sgRNAs, showing efficacy in treating HT-I and MPS-I mouse models.

Nature Communications · Nov 1, 2021Peer-reviewedMolecular Biology