A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike
Ying Fu, Juliana da Fonseca Rezende e Mello, Bryan D. Fleming, Alex Renn, Catherine Z. Chen, Xin Hu, Miao Xu, Kirill Gorshkov, Quinlin Hanson, Wei Zheng, Emily M. Lee, Lalith Perera, Robert M. Petrovich, Manisha Pradhan, Richard T. Eastman, , Anton M. Simeonov
This paper develops potent humanized nanobodies against SARS-CoV-2 spike protein, showing effectiveness against the Alpha variant and providing structural insights into their neutralization mechanism.
PLoS ONE · Aug 10, 2022Peer-reviewedSynthetic Biology