Author

Manisha Pradhan

National Center for Advancing Translational SciencesORCID 0000-0002-8710-0148Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Catherine Z. CheniD· 2 shared Miao XuiD· 2 shared Wei ZhengiD· 2 shared Alex RenniD· 1 shared Allen L. HsuiD· 1 shared Anne G. BangiD· 1 shared Anton M. SimeonoviD· 1 shared Beatrice CubittiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersSynthetic Biology

Catherine Z. ChenORCID

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2 papers

Recent·Most cited

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike

Ying Fu, Juliana da Fonseca Rezende e Mello, Bryan D. Fleming, Alex Renn, Catherine Z. Chen, Xin Hu, Miao Xu, Kirill Gorshkov, Quinlin Hanson, Wei Zheng, Emily M. Lee, Lalith Perera, Robert M. Petrovich, Manisha Pradhan, Richard T. Eastman, , Anton M. Simeonov

This paper develops potent humanized nanobodies against SARS-CoV-2 spike protein, showing effectiveness against the Alpha variant and providing structural insights into their neutralization mechanism.

PLoS ONE · Aug 10, 2022Peer-reviewedSynthetic Biology

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism

Fadi Jacob, Sarshan R. Pather, Wei‐Kai Huang, Feng Zhang, Samuel Zheng Hao Wong, Haowen Zhou, Beatrice Cubitt, Wenqiang Fan, Catherine Z. Chen, Miao Xu, Manisha Pradhan, Daniel Y. Zhang, Wei Zheng, Anne G. Bang, Hongjun Song, , Guo‐li Ming

This study shows SARS-CoV-2 can infect brain cells and organoids derived from human induced pluripotent stem cells, leading to cell death and inflammation, and suggests using these models to study the virus's effects on the brain.

Cell stem cell · Sep 21, 2020Peer-reviewedNeuroscience