Reactive astrocytes promote proteostasis in Huntington disease through the JAK2-STAT3 pathway
Laurene Abjean, Lucile Ben Haim, Miriam Riquelme‐Perez, Pauline Gipchtein, Céline Derbois, Marie-Ange Palomares, Fanny Petit, Anne‐Sophie Hérard, Marie‐Claude Gaillard, Martine Guillermier, Mylène Gaudin, Gwennaëlle Aurégan, Nisrine Sagar, Cameron Héry, Noëlle Dufour, , Carole Escartin
This study shows that activating the JAK2-STAT3 pathway in astrocytes reduces mutant Huntingtin aggregates and improves disease outcomes in Huntington's disease models.
Brain · Feb 17, 2022Peer-reviewedNeuroscience