Increased Genetic Protection Against Alzheimer's Disease in Centenarians
Harold T. Bae, Zeyuan Song, Amanat Ali, Takashi Sasaki, Niccoló Tesi, Hannah J. Lords, Anastasia Leshchyk, Yukiko Abe, Nobuyoshi Hirose, Yasumichi Arai, Nir Barzilai, Erica F Weiss, Marc Hulsman, Sven J. van der Lee, Natasja M. van Schoor, , Paola Sebastiani B
This study constructs a polygenic protective score for Alzheimer's disease and finds stronger genetic protection against AD in centenarians compared to non-longevity individuals.
GeroScience · Jul 4, 2025Peer-reviewedGenetics