Pinchas Cohen

Temporal control of mitochondrial mutagenesis reveals the fate of mtDNA mutations with age

This study shows that mtDNA mutations arising early in life drive age-related pathologies and that mitochondrial fusion modulates their selection, suggesting interventions targeting fusion could slow aging.

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome

This study shows that reduced IGF-1 signaling extends lifespan in mammals but not in mitochondrial mutator mice, indicating that mitochondrial genome stability is essential for the longevity benefits of IGF-1 suppression.

Nuclear Mitochondrial Interaction Test Reveals Sex-Dependent Mitochondrial SNPs Interacting with Klotho Variants on Diabetes Risk

The paper identifies mitochondrial SNPs interacting with Klotho variants to influence diabetes risk, showing sex-dependent effects using the NuMIT method.

A Pro-Diabetogenic mtDNA Polymorphism in the Mitochondrial-Derived Peptide, MOTS-c

The paper identifies a mtDNA polymorphism in MOTS-c associated with increased T2D risk in males, interacting with physical activity.