Immunotherapy-related cognitive impairment after CAR T cell therapy in mice
Anna C. Geraghty, Lehi Acosta-Alvarez, Maria Caterina Rotiroti, Selena Dutton, Michael R. O’Dea, Won‐Ju Kim, Vrunda S. Trivedi, Rebecca A. Mancusi, Kiarash Shamardani, Karen E. Malacon, Pamelyn J. Woo, Naiara Martínez-Vélez, Theresa Pham, Noemi Reche-Ley, Gabriel Otubu, , Michelle Monje
This study shows that CAR T cell therapy in mice causes cognitive impairment through CNS immune dysregulation, microglial reactivity, and disrupted oligodendroglial homeostasis.
Cell · May 12, 2025Peer-reviewedNeuroscience