Author

J. A. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Immunology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Approach:experimental assay· 4 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Dhar· 2 shared D. Ralph· 2 shared F. A. Matsen· 2 shared J. Overbaugh· 2 shared K. K. Lee· 2 shared Z. Yaffe· 2 shared A. C. Palmer· 1 shared A. Khan· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

A. Dhar

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Developing and Investigating a Nanovibration Intervention for the Prevention/Reversal of Bone Loss Following Spinal Cord Injury

J. A. Williams, P. Campsie, R. Gibson, O. Johnson-Love, A. S. Werber, M. Sprott, R. Meechan, C. Huesa, J. F. C. Windmill, M. Purcell, S. Coupaud, M. J. Dalby, P. G. Childs, J. S. Riddell, S. Reid

This study tests a nanovibration device for reversing bone loss after spinal cord injury in rats, finding no reversal but increased collagen synthesis markers.

bioRxiv · Feb 12, 2024Bioengineering

Engineered 3D environments reprogram fibroblast-mediated inflammation in rheumatoid Arthritis.

A. Khan, P. Pan, J. Isakova, Y. Lan, C. Cil, Y. Wang, T. Rogkoti, T. Sartyoungkul, J. Windmill, J. A. Williams, M. Salmeron-Sanchez, M. M. Harnett, O. Dobre, M. Pineda

This study shows that 3D environments influence fibroblast inflammation in rheumatoid arthritis, with soft hydrogels promoting a resolving phenotype and stiff scaffolds restoring inflammatory profiles.

bioRxiv · Dec 21, 2022 · PreprintBioengineering

Eastern Equine Encephalitis Virus Rapidly Infects and Disseminates in the Brain and Spinal Cord of Infected Cynomolgus Macaques Following Aerosol Challenge

J. A. Williams, S. Y. Long, X. Zeng, K. Kuehl, A. M. Babka, N. M. Davis, J. Liu, J. C. Trefry, S. Daye, P. R. Facemire, P. L. Iversen, S. Bavari, M. L. Pitt, F. Nasar

This study investigates EEEV pathogenesis in cynomolgus macaques following aerosol challenge, finding that the virus replicates in the olfactory bulb and spreads via axonal transport, causing neuronal dysfunction rather than death.

bioRxiv · Dec 21, 2020Microbiology

Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodies

L. E. Doepker, S. Danon, E. Harkins, D. Ralph, Z. Yaffe, A. Dhar, C. Wagner, M. Stumpf, D. Arenz, J. A. Williams, W. Jaoko, K. Mandaliya, K. K. Lee, F. A. Matsen, J. Overbaugh

This study reconstructs the developmental pathways of HIV-specific ADCC antibodies and identifies mutations required for antigen binding and ADCC function.

bioRxiv · Sep 24, 2020 · PreprintImmunology

Biomarker-guided treatment strategies for ovarian cancer identified from a heterogeneous panel of patient-derived tumor xenografts

A. C. Palmer, D. Plana, H. Gao, J. M. Korn, G. Yang, J. Green, X. Zhang, R. Velazquez, M. E. McLaughlin, D. A. Ruddy, C. Kowal, J. Goldovitz, C. Bullock, S. Rivera, D. Rakiec, , J. A. Williams

This study identifies biomarker-guided treatment strategies for ovarian cancer using patient-derived tumor xenografts, finding that nearly 90% of PDXs responded to at least one targeted therapy.

bioRxiv · Jan 8, 2020Cancer Biology

Rapid development of an infant-derived HIV-1 broadly neutralizing antibody lineage

C. A. Simonich, L. Doepker, D. Ralph, J. A. Williams, A. Dhar, Z. Yaffe, L. Gentles, C. T. Small, B. Oliver, V. Vigdorovich, V. Mangala Prasad, R. Nduati, D. N. Sather, K. K. Lee, F. A. Matsen, J. Overbaugh

This study reconstructs the developmental lineage of an infant-derived HIV-1 broadly neutralizing antibody, showing a rapid evolution with fewer mutations compared to adult antibodies.

bioRxiv · Sep 13, 2018Immunology