Author

M. W. Loeffler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. N. R. Weber· 3 shared F. Herster· 3 shared A. Marcu· 2 shared A. N. Weber· 2 shared H. Kalbacher· 2 shared K. Ghoreschi· 2 shared K. Schaekel· 2 shared S. Dickhoefer· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

A. N. R. Weber

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Author profile →

6 papers

Recent·Most cited

Release of the pre-assembled naRNA-LL37 composite DAMP re-defines neutrophil extracellular traps (NETs) as intentional DAMP webs

F. Bork, C. L. Greve, C. Youn, S. Chen, Y. Wang, M. Nasri, J. Focken, J. Scheurer, P. Engels, M. Dubbelaar, K. Hipp, B. Schittek, S. Bugl, M. W. Loeffler, J. Skokowa, , A. N. Weber

This study identifies naRNA as a pre-assembled composite DAMP in neutrophils that drives NET formation and inflammation via TLR8/TLR13, redefining NETs as intentional inflammatory agents.

bioRxiv · Jul 26, 2022 · PreprintImmunology

A base-line cellular antiviral state is maintained by cGAS and its most frequent naturally occurring variant rs610913

J. Kazmierski, C. Elsner, K. Doehner, S. Xu, A. Ducroux, F. Pott, J. Jansen, C. W. Thorball, O. Zeymer, X. Zhou, R. Fedorov, J. Fellay, M. W. Loeffler, A. N. R. Weber, B. Sodeik, C. Goffinet

This study shows that the cGAS variant rs610913 maintains a baseline antiviral state, slightly altering susceptibility to viral infections without gross phenotypic differences.

bioRxiv · Aug 24, 2021 · PreprintImmunology

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity

Z. A. Bittner, X. Liu, S. Shankar, A. Tapia Abellan, H. Kalbacher, L. Andreeva, M. Mangan, P. Duewell, M. Lovotti, K. Bosch, S. Dickhoefer, A. Marcu, S. Stevanovic, F. Herster, M. W. Loeffler, , A. N. Weber

The paper shows BTK modulates NLRP3 inflammasome activity through phosphorylation of tyrosine residues, affecting localization, oligomerization, and IL-1β release.

bioRxiv · Jun 25, 2020Immunology

An innovative approach for HLA typing, molecular tumor testing and the validation of tumor exclusive antigens

M. Ghosh, L. Bichmann, J. Scheid, G. Gueler, H. Schuster, M. Di Marco, A. Marcu, M. Beyer, A. Nelde, L. K. Freudenmann, L. Muehlenbruch, M. W. Loeffler, O. Kohlbacher, H.-G. Rammensee, S. Stevanovic

The paper describes an innovative approach for HLA typing, molecular tumor testing, and validation of tumor-exclusive antigens but has been withdrawn by the authors.

bioRxiv · Jun 5, 2020 · PreprintImmunology

Neutrophil-extracellular trap-associated RNA (naRNA) and LL37 enable self-amplifying inflammation in psoriasis

F. Herster, Z. Bittner, S. Dickhoefer, D. Eisel, T. Eigenbrod, T. Knorpp, N. Schneiderhan-Marra, M. W. Loeffler, H. Kalbacher, D. Hartl, L. Freund, K. Schaekel, M. Heiser, K. Ghoreschi, A. N. R. Weber

The paper shows RNA-LL37 complexes activate neutrophils via TLR8, leading to cytokine release and NET formation, which may drive self-sustaining inflammation in psoriasis.

bioRxiv · Feb 19, 2019 · PreprintImmunology

Platelet-neutrophil aggregates promote skin pathology in psoriasis

F. Herster, Z. Bittner, M. C. Codrea, N. Archer, M. Heister, M. W. Loeffler, S. Heumos, J. Wegner, R. Businger, M. Schindler, D. Stegner, K. Schaekel, S. Grabbe, K. Ghoreschi, L. Miller, A. N. R. Weber

This study identifies platelet-neutrophil aggregates as contributors to psoriasis skin pathology and disease severity.

bioRxiv · Jan 28, 2019 · PreprintImmunology