C. T. Watson

Ultrasensitive allele inference from immune repertoire sequencing data with MiXCR

The paper introduces an algorithm for ultra-sensitive allele inference from immune repertoire sequencing data, demonstrating its accuracy and application in diverse populations.

Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry

The paper uses long-read sequencing to resolve haplotype variation and genetic architecture in the human IGK locus across diverse ancestries, identifying novel variants and population-specific allele frequencies.

FLAIRR-seq: A novel method for single molecule resolution of near full-length immunoglobulin heavy chain repertoires

FLAIRR-seq provides high-resolution, single-molecule characterization of immunoglobulin heavy chain repertoires, including constant region features, and identifies novel alleles.

Characterization of Extensive Diversity In Immunoglobulin Light Chain Variable Germline Genes Across Biomedically Important Mouse Strains

The paper catalogs germline immunoglobulin light chain variable genes in 18 mouse strains, finding extensive undocumented diversity not present in IMGT.

A BALB/c IGHV Reference Set, defined by haplotype analysis of long-read VDJ-C sequences from F1 (BALB/c / C57BL/6) mice

The paper defines a BALB/c IGHV reference set by analyzing long-read VDJ-C sequences from F1 mice, identifying strain-specific variations and germline alleles not present in existing genome references.

Revealing how variations in antibody repertoires correlate with vaccine responses

The paper analyzes antibody repertoire variations in vaccinated calves to identify genetic factors influencing vaccine efficacy against bovine respiratory disease.

T Cell Receptor Beta Germline Variability is Revealed by Inference From Repertoire Data

The paper identifies undocumented polymorphisms in T cell receptor Beta genes using AIRR-seq data and shows how a single SNP affects TCR repertoire composition.

Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naive human B cells

The paper screens naive B cells for VRC01-class broadly neutralizing antibody precursors using a germline-targeting immunogen and single-cell BCR sequencing, finding common germline variation affecting gene usage.

A comparison of immunoglobulin IGHV, IGHD and IGHJ genes in wild-derived and classical inbred mouse strains

The paper compares immunoglobulin gene diversity in wild-derived and classical inbred mouse strains, finding novel alleles and highlighting genetic complexity in IGH loci.

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

This study shows that slow delivery immunization in rhesus macaques increases HIV-neutralizing antibody titers and germinal center responses by modulating immunodominance.