Author

O. Miotto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:plant (other)· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Amaratunga· 2 shared D. P. Kwiatkowski· 2 shared R. Amato· 2 shared R. D. Pearson· 2 shared S. Suon· 2 shared A. Barry· 1 shared A. M. Dondorp· 1 shared A. Simeonov· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

C. Amaratunga

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

O. Miotto, M. Sekihara, S.-I. Tachibana, M. Yamauchi, R. D. Pearson, R. Amato, S. Goncalves, S. Mehra, R. Noviyanti, J. Marfurt, S. Auburn, R. N. Price, I. Mueller, M. Ikeda, T. Mori, , T. Mita

The paper identifies the emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations in Papua New Guinea and suggests an independent origin with distinct genetic features.

PLOS Pathogens · Dec 15, 2020Peer-reviewedMicrobiology

Modulation of triple artemisinin-based combination therapy pharmacodynamics by Plasmodium falciparum genotype

M. R. Ansbro, Z. Itkin, L. Chen, G. Zahoranszky-Kohalmi, C. Amaratunga, O. Miotto, T. Peryea, C. V. Hobbs, S. Suon, J. M. S, A. M. Dondorp, R. W. van der Pluijm, T. Wellems, A. Simeonov, R. T. Eastman

The paper evaluates drug-drug interactions in triple artemisinin-based combination therapies (TACTs) using an in vitro high-throughput process to identify genotype-dependent susceptibility and antagonism.

ACS Pharmacology & Translational Science · Dec 11, 2020Peer-reviewedMicrobiology

Origins of the current outbreak of multidrug resistant malaria in Southeast Asia: a retrospective genetic study

R. Amato, R. D. Pearson, J. Almagro-Garcia, C. Amaratunga, P. Lim, S. Suon, S. Sreng, E. Drury, J. Stalker, O. Miotto, R. M. Fairhurst, D. P. Kwiatkowski

This study identifies the genetic origins of multidrug-resistant malaria in Southeast Asia by analyzing genome sequences from 2007 to 2013, revealing a dominant lineage linked to artemisinin and piperaquine resistance.

bioRxiv · Oct 24, 2017Evolutionary Biology