Author

R. D. Pearson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:plant (other)· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. P. Kwiatkowski· 2 shared O. Miotto· 2 shared R. Amato· 2 shared A. Barry· 1 shared A. M. Dondorp· 1 shared A. Ruecker· 1 shared A.-C. Uhlemann· 1 shared B. Sornboon· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersMicrobiology

D. P. Kwiatkowski

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Author profile →

4 papers

Recent·Most cited

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

K. Kumpornsin, T. Kochakarn, T. Yeo, M. Luth, R. D. Pearson, J. Hoshizaki, K. Schindler, S. Mok, H. Park, A.-C. Uhlemann, S. M. Cubel, V. Franco, M. Gomez-Lorenzo, F.-J. Gamo, E. Winzeler, , M. C. Lee

This study creates a mutator parasite of Plasmodium falciparum to enhance drug resistance discovery by increasing mutation rates and identifying resistance mechanisms.

bioRxiv · Aug 23, 2022 · PreprintMicrobiology

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

O. Miotto, M. Sekihara, S.-I. Tachibana, M. Yamauchi, R. D. Pearson, R. Amato, S. Goncalves, S. Mehra, R. Noviyanti, J. Marfurt, S. Auburn, R. N. Price, I. Mueller, M. Ikeda, T. Mori, , T. Mita

The paper identifies the emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations in Papua New Guinea and suggests an independent origin with distinct genetic features.

PLOS Pathogens · Dec 15, 2020Peer-reviewedMicrobiology

Artemisinin-resistant malaria parasites show enhanced transmission to mosquitoes under drug pressure

K. Witmer, F. A. Dahalan, M. J. Delves, S. Yahiya, O. J. Watson, U. Straschil, D. Chiwcharoen, B. Sornboon, S. Pukrittayakamee, R. D. Pearson, V. Howick, M. Lawniczak, N. J. White, A. M. Dondorp, L. C. Okell, , J. Baum

Artemisinin-resistant malaria parasites show reduced sensitivity to transmission-blocking effects of artemisinin drugs, increasing their transmission to mosquitoes under drug pressure.

bioRxiv · Feb 4, 2020Microbiology

Origins of the current outbreak of multidrug resistant malaria in Southeast Asia: a retrospective genetic study

R. Amato, R. D. Pearson, J. Almagro-Garcia, C. Amaratunga, P. Lim, S. Suon, S. Sreng, E. Drury, J. Stalker, O. Miotto, R. M. Fairhurst, D. P. Kwiatkowski

This study identifies the genetic origins of multidrug-resistant malaria in Southeast Asia by analyzing genome sequences from 2007 to 2013, revealing a dominant lineage linked to artemisinin and piperaquine resistance.

bioRxiv · Oct 24, 2017Evolutionary Biology