Author

D. P. Kwiatkowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Evolutionary Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:whole-genome sequencing· 4 Organism:human· 3 Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2

Frequent Co-Authors

E. Drury· 4 shared G. A. Awandare· 3 shared L. B. Stewart· 3 shared S. Goncalves· 3 shared A. Claessens· 2 shared D. J. Conway· 2 shared D. Weetman· 2 shared K. A. Rockett· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersMicrobiology

E. Drury

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Associations between the Plasmodium falciparum genome and sickle haemoglobin identified in mild malaria cases from Ghana

W. L. Hamilton, A. J. Forster, Y. Aniweh, V. Asoala, E. Drury, K. A. Rockett, G. A. Awandare, D. P. Kwiatkowski, G. Band, L. N. Amenga-Etego

The paper identifies a new P. falciparum locus associated with sickle haemoglobin in mild malaria cases from Ghana, replicating previous findings and suggesting further research is needed.

bioRxiv · Sep 14, 2023Microbiology

Genomic variation during culture-adaptation of genetically complex Plasmodium falciparum clinical isolates

A. Claessens, L. B. Stewart, E. Drury, A. D. Ahouidi, A. Amambua-Ngwa, M. Diakite, D. P. Kwiatkowski, G. A. Awandare, D. J. Conway

The paper analyzes genomic variation in Plasmodium falciparum clinical isolates during culture adaptation, finding that some isolates fix to single genotypes while others retain diversity, with loss-of-function mutants emerging in multiple-genotype infections.

bioRxiv · Sep 14, 2022 · PreprintMicrobiology

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

O. Miotto, M. Sekihara, S.-I. Tachibana, M. Yamauchi, R. D. Pearson, R. Amato, S. Goncalves, S. Mehra, R. Noviyanti, J. Marfurt, S. Auburn, R. N. Price, I. Mueller, M. Ikeda, T. Mori, , T. Mita

The paper identifies the emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations in Papua New Guinea and suggests an independent origin with distinct genetic features.

PLOS Pathogens · Dec 15, 2020Peer-reviewedMicrobiology

Intrinsic multiplication rate variation and plasticity of human blood stage malaria parasites

L. B. Stewart, O. Diez-Ingelmo, A. Claessens, J. Abugri, R. Pearson, S. Goncalves, E. Drury, D. P. Kwiatkowski, G. A. Awandare, D. J. Conway

The paper shows that variation in the multiplication rate of Plasmodium falciparum correlates with infection intensity and virulence in human malaria.

Communications Biology · Oct 28, 2020Peer-reviewedMicrobiology

Multi-locus genotyping reveals established endemicity of a geographically distinct Plasmodium vivax population in Mauritania, West Africa

H. Ba, S. Auburn, C. G. Jacob, S. Goncalves, C. W. Duffy, L. B. Stewart, R. N. Price, Y. B. Deh, M. Y. Diallo, A. Tndia, D. P. Kwiatkowski, D. Conway

This paper uses multi-locus genotyping to show that Plasmodium vivax in Mauritania is genetically diverse and endemic, with no evidence of recent introduction or epidemic structure.

bioRxiv · Sep 10, 2020Microbiology

A high throughput multi-locus insecticide resistance marker panel for tracking resistance emergence and spread in Anopheles gambiae

E. Lucas, K. A. Rockett, A. Lynd, J. Essandoh, N. Grisales, B. Kemei, H. Njoroge, C. Hubbart, E. J. Rippon, J. Morgan, A. Van't Hof, E. O. Ochomo, D. P. Kwiatkowski, D. Weetman, M. J. Donnelly

The paper develops a 28-marker genotyping panel to track insecticide resistance in Anopheles gambiae, identifying four resistance-associated mutations and geographic diversity in kdr resistance.

bioRxiv · Mar 31, 2019Evolutionary Biology

Whole genome sequencing reveals high complexity of copy number variation at insecticide resistance loci in malaria mosquitoes

E. R. Lucas, A. Miles, N. J. Harding, C. S. Clarkson, M. K. N. Lawniczak, D. P. Kwiatkowski, D. Weetman, M. J. Donnelly, The Anopheles gambiae 1000 Genomes Consortium

The paper uses whole-genome sequencing to identify copy number variations (CNVs) in Anopheles gambiae linked to insecticide resistance, finding CNVs enriched for resistance-related genes and under positive selection.

bioRxiv · Aug 25, 2018Evolutionary Biology

Origins of the current outbreak of multidrug resistant malaria in Southeast Asia: a retrospective genetic study

R. Amato, R. D. Pearson, J. Almagro-Garcia, C. Amaratunga, P. Lim, S. Suon, S. Sreng, E. Drury, J. Stalker, O. Miotto, R. M. Fairhurst, D. P. Kwiatkowski

This study identifies the genetic origins of multidrug-resistant malaria in Southeast Asia by analyzing genome sequences from 2007 to 2013, revealing a dominant lineage linked to artemisinin and piperaquine resistance.

bioRxiv · Oct 24, 2017Evolutionary Biology