Author

O. P. B. Wiklander

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Gupta· 3 shared J. Hean· 3 shared S. EL Andaloussi· 3 shared X. Liang· 3 shared A. Gorgens· 2 shared A. M. Zickler· 2 shared G. Corso· 2 shared G. Zhou· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioengineering

D. Gupta

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Author profile →

4 papers

Recent·Most cited

Histones are exosome membrane proteins regulated by cell stress

B. Singh, M. F. Sundbom, U. Muthukrishnan, B. Natarajan, S. Stransky, J. Z. Nordin, O. P. B. Wiklander, L. Sandblad, S. Sidoli, S. EL Andaloussi, M. Haney, J. D. Gilthorpe

This study identifies histones as exosome membrane proteins regulated by cell stress, showing they are secreted via the exosome pathway and lack nuclear post-translational modifications.

bioRxiv · Apr 8, 2024 · PreprintCell Biology

Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery

X. Liang, D. Gupta, J. Xie, E. V. Wonterghem, L. V. Hoecke, J. Hean, Z. Niu, O. P. B. Wiklander, W. Zheng, R. J. Wiklander, R. He, D. R. Mamand, J. Bost, G. Zhou, H. Zhou, , S. EL Andaloussi

This paper develops VEDIC and VFIC systems for efficient intracellular protein delivery using engineered extracellular vesicles, achieving high recombination and genome editing efficiency in vitro and in vivo.

bioRxiv · Apr 30, 2023 · PreprintBioengineering

Novel endogenous engineering platform for robust loading and delivery of functional mRNA by extracellular vesicles

A. M. Zickler, X. Liang, D. Gupta, D. Mamand, M. de Luca, G. Corso, L. Errichelli, J. Hean, T. Sen, O. M. Elsharkasy, N. Kamei, Z. Niu, G. Zhou, H. Zhou, S. Roudi, , S. EL Andaloussi

This paper develops an mRNA delivery system using extracellular vesicles engineered with RNA-binding domains and fusogenic moieties, showing improved efficacy in a melanoma model.

bioRxiv · Mar 17, 2023Bioengineering

Engineering of extracellular vesicles for display of protein biotherapeutics

D. Gupta, O. P. B. Wiklander, A. Gorgens, M. Conceicao, G. Corso, X. Liang, Y. Seow, S. Balsu, U. Felldin, B. Bostancioglu, Y. X. F. Lee, J. Hean, I. Mager, T. C. Roberts, M. Gustafsson, , S. E. Andaloussi

This paper develops a platform to display multiple protein therapeutics on extracellular vesicles, showing improved efficacy in inflammatory disease models compared to existing biologics.

bioRxiv · Jun 14, 2020Bioengineering