Author

T. C. Roberts

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

M. J. A. Wood· 4 shared I. Mager· 3 shared A. Gorgens· 2 shared D. Gupta· 2 shared J. Hean· 2 shared M. Conceicao· 2 shared O. P. B. Wiklander· 2 shared S. E. Andaloussi· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersBioengineering

M. J. A. Wood

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery

X. Liang, D. Gupta, J. Xie, E. V. Wonterghem, L. V. Hoecke, J. Hean, Z. Niu, O. P. B. Wiklander, W. Zheng, R. J. Wiklander, R. He, D. R. Mamand, J. Bost, G. Zhou, H. Zhou, , S. EL Andaloussi

This paper develops VEDIC and VFIC systems for efficient intracellular protein delivery using engineered extracellular vesicles, achieving high recombination and genome editing efficiency in vitro and in vivo.

bioRxiv · Apr 30, 2023 · PreprintBioengineering

Extracellular vesicle-mediated promotion of myogenic differentiation is dependent on dose, collection media composition, and isolation method

B. Hanson, M. Conceicao, Y. Lomonosova, I. Mager, P. L. Puri, S. EL Andaloussi, M. J. A. Wood, T. C. Roberts

This study shows that extracellular vesicles promote myogenic differentiation in C2C12 cells, but their effectiveness depends on dose, collection media, and isolation method.

bioRxiv · Aug 22, 2022Cell Biology

Engineering of extracellular vesicles for display of protein biotherapeutics

D. Gupta, O. P. B. Wiklander, A. Gorgens, M. Conceicao, G. Corso, X. Liang, Y. Seow, S. Balsu, U. Felldin, B. Bostancioglu, Y. X. F. Lee, J. Hean, I. Mager, T. C. Roberts, M. Gustafsson, , S. E. Andaloussi

This paper develops a platform to display multiple protein therapeutics on extracellular vesicles, showing improved efficacy in inflammatory disease models compared to existing biologics.

bioRxiv · Jun 14, 2020Bioengineering

The Viral Protein Corona Directs Viral Pathogenesis and Amyloid Aggregation

K. Ezzat, M. Pernemalm, S. Palsson, T. C. Roberts, P. Jarver, A. Dondalska, B. Bestas, M. J. Sobkowiak, B. Levanen, M. Skold, E. A. Thompson, O. Saher, O. K. Kari, T. Lajunen, E. Sverremark Ekstrom, , S. E. Andaloussi

This study shows that viruses form protein coronas that affect infectivity, immune activation, and amyloid aggregation, linking viral and amyloid pathologies.

bioRxiv · Apr 21, 2019Microbiology