Chromatin regulator HELLS mediates SSB repair and responses to DNA alkylation damage.
Joyous T. Joseph, Christine M. Wright, Estanislao Peixoto, Etsuko Shibata, Asad Ullah Khan, Yong Li, Jason Romero Neidigk, Bo-Ruei Chen, Saba Tufail, Aaiyas Mujawar, Olivia Decker, Krishna Reethika Kadali, Azait Imtiaz, Brianna A Jones, Yanfeng Zhang, , Wioletta Czaja
This study identifies HELLS as a regulator of SSB repair and DNA alkylation damage response, showing its synthetic lethality with HRD in cancer.
Nucleic Acids Research · Oct 21, 2025Peer-reviewedMolecular Biology