Viperin binds STING and enhances the type-I interferon response following dsDNA detection
K. M. Crosse, E. A. Monson, A. B. Dumbrepatil, M. Smith, Y.-Y. Tseng, K. H. Van der Hoek, P. A. Revill, D. C. Tscharke, E. N. G. Marsh, M. R. Beard, K. J. Helbig
This study identifies Viperin's role in enhancing the type-I interferon response by binding STING and promoting TBK1 ubiquitination, thereby strengthening antiviral immunity against dsDNA.
bioRxiv · Dec 17, 2019Immunology