Author

K. J. Helbig

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

E. A. Monson· 3 shared D. R. Whelan· 2 shared K. M. Crosse· 2 shared A. B. Dumbrepatil· 1 shared A. J. Milligan· 1 shared A. M. Rozario· 1 shared A. Mechler· 1 shared C. Johnson· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

E. A. Monson

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Author profile →

3 papers

Recent·Most cited

Virally induced lipid droplets are a platform for innate immune signalling complexes

E. A. Monson, J. L. Laws, Z. Telikani, A. J. Milligan, A. M. Rozario, I. Amarasinghe, M. L. Smith, V. Tran, Q. Dinh, N. A. Williamson, A. Mechler, C. Johnson, M. J. Hofer, S. Nie, D. R. Whelan, K. J. Helbig

This study shows that virally induced lipid droplets host antiviral signaling proteins and undergo dynamic proteome and lipidome changes to support innate immune responses.

bioRxiv · Apr 20, 2023 · PreprintImmunology

Intracellular Lipid Droplet Accumulation Occurs Early Following Viral Infection and Is Required for an Efficient Interferon Response

E. A. Monson, K. M. Crosse, E. Duan, W. Chen, R. D. O'Shea, L. M. Wakem, D. R. Whelan, K. J. Helbig

The paper shows that lipid droplets form early after viral infection, support interferon production, and reduce viral replication.

Nature Communications · Jul 14, 2021Peer-reviewedMicrobiology

Viperin binds STING and enhances the type-I interferon response following dsDNA detection

K. M. Crosse, E. A. Monson, A. B. Dumbrepatil, M. Smith, Y.-Y. Tseng, K. H. Van der Hoek, P. A. Revill, D. C. Tscharke, E. N. G. Marsh, M. R. Beard, K. J. Helbig

This study identifies Viperin's role in enhancing the type-I interferon response by binding STING and promoting TBK1 ubiquitination, thereby strengthening antiviral immunity against dsDNA.

bioRxiv · Dec 17, 2019Immunology