Author

D. C. Tscharke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

A. B. Dumbrepatil· 1 shared A. Phillips· 1 shared A. Sette· 1 shared A. W. Purcell· 1 shared B. Peters· 1 shared E. A. Monson· 1 shared E. N. G. Marsh· 1 shared K. H. Van der Hoek· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperImmunology

A. B. Dumbrepatil

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Author profile →

3 papers

Recent·Most cited

Genomic location dictates lytic promoter activity during herpes simplex virus latency

N. Singh, S. Zacharaiah, A. Phillips, D. C. Tscharke

The paper shows that lytic gene promoters in HSV-1 are active during latency only when located near the LAT locus.

bioRxiv · Dec 5, 2023 · PreprintMicrobiology

Viperin binds STING and enhances the type-I interferon response following dsDNA detection

K. M. Crosse, E. A. Monson, A. B. Dumbrepatil, M. Smith, Y.-Y. Tseng, K. H. Van der Hoek, P. A. Revill, D. C. Tscharke, E. N. G. Marsh, M. R. Beard, K. J. Helbig

This study identifies Viperin's role in enhancing the type-I interferon response by binding STING and promoting TBK1 ubiquitination, thereby strengthening antiviral immunity against dsDNA.

bioRxiv · Dec 17, 2019Immunology

Benchmarking predictions of MHC class I restricted T cell epitopes

S. Paul, N. P. Croft, A. W. Purcell, D. C. Tscharke, A. Sette, M. Nielsen, B. Peters

This study benchmarks T cell epitope prediction tools using a comprehensive dataset of vaccinia virus epitopes, finding that neural network-based methods trained on MHC binding and ligand elution data perform best.

bioRxiv · Jul 8, 2019 · PreprintImmunology