Author

M. R. Beard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

E. N. Kirby· 2 shared O. Romeo· 2 shared A. B. Dumbrepatil· 1 shared A. P. Chilver· 1 shared A. Ruszkiewicz· 1 shared B. M. Tran· 1 shared B. N. Trowbridge· 1 shared B. Shue· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

E. N. Kirby

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The utility of CRISPR activation as a platform to identify interferon stimulated genes with anti-viral function

E. N. Kirby, X. B. Montin, T. P. Allen, J. Densumite, B. N. Trowbridge, M. R. Beard

This study uses CRISPR activation to identify anti-viral ISGs by testing their ability to prevent viral replication and cytopathic effects.

bioRxiv · Aug 28, 2023Microbiology

Constitutive expression and distinct properties of IFN-epsilon protect the female reproductive tract from Zika virus infection

R. Coldbeck-Shackley, O. Romeo, S. Rosli, L. J. Gearing, J. A. Gould, S. S. Lim, K. Van der Hoek, N. S. Eyre, B. Shue, S. A. Robertson, S. M. Best, M. D. Tate, P. Hertzog, M. R. Beard

This paper shows that IFN-epsilon's constitutive expression in the female reproductive tract provides innate antiviral protection against Zika virus by resisting viral antagonism and enhancing antiviral activity.

PLOS Pathogens · Mar 10, 2023Peer-reviewedImmunology

Human Liver Organoids as a Patient-derived Model for HBV Infection and Cellular Response

C. K. Lim, O. Romeo, A. P. Chilver, B. M. Tran, D. Flanagan, E. N. Kirby, J. Breen, E. Vincan, N. Warner, E. M. McCartney, M. Van der Hoek, A. Ruszkiewicz, E. Tse, M. R. Beard

This paper develops a liver organoid model to study HBV infection and antiviral responses, showing it supports the full HBV lifecycle and can assess drug and immunomodulator effects.

bioRxiv · Oct 20, 2022 · PreprintMicrobiology

Viperin binds STING and enhances the type-I interferon response following dsDNA detection

K. M. Crosse, E. A. Monson, A. B. Dumbrepatil, M. Smith, Y.-Y. Tseng, K. H. Van der Hoek, P. A. Revill, D. C. Tscharke, E. N. G. Marsh, M. R. Beard, K. J. Helbig

This study identifies Viperin's role in enhancing the type-I interferon response by binding STING and promoting TBK1 ubiquitination, thereby strengthening antiviral immunity against dsDNA.

bioRxiv · Dec 17, 2019Immunology