Author

P. A. Thibault

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. Lee· 3 shared A. Park· 2 shared P. Hong· 2 shared A. Gowlikar· 1 shared A. Lam· 1 shared B. A. Garcia· 1 shared B. A. Lee· 1 shared C. B. Lopez· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMicrobiology

B. Lee

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery and gene editing in primary human cells

C. S. Stevens, J. Carmichael, R. Watkinson, S. S. Kowdle, R. A. Reis, K. Hamane, J. Jang, A. Park, O. Pernet, W. Khamaikawin, P. Hong, P. A. Thibault, A. Gowlikar, D. S. An, B. Lee

This paper develops a temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery, achieving high gene editing efficiency in human cells without triggering immune responses.

bioRxiv · May 3, 2024 · PreprintMicrobiology

Single virus assay reveals membrane determinants and mechanistic features of Sendai virus binding

A. Lam, O. O. Kirkland, P. F. Anderson, N. Seetharaman, D. Vujovic, P. A. Thibault, K. D. Azarm, B. A. Lee, R. J. Rawle

This study uses a single virus assay to investigate Sendai virus binding mechanisms, identifying receptor structural features, cooperative binding, cholesterol dependence, and a rolling mobility mechanism.

bioRxiv · Nov 23, 2021Biophysics

miR-122 affects both the initiation and maintenance of Hepatitis C Virus infections

M. Panigrahi, P. A. Thibault, J. A. Wilson

This study shows miR-122 is essential for initiating HCV infection but has a minor role in maintaining it, with implications for anti-miR-122 therapy.

bioRxiv · Nov 4, 2021Microbiology

The Viral Polymerase Complex Mediates the Interaction of vRNPs with Recycling Endosomes During SeV Assembly

E. Genoyer, K. Kulej, C.-t. Hung, P. A. Thibault, K. Azarm, T. Takimoto, B. A. Garcia, B. Lee, S. Lakdawala, M. D. Weitzman, C. B. Lopez

The paper identifies viral polymerase complex components L and C as mediators of vRNP interaction with Rab11a-marked recycling endosomes during SeV assembly.

bioRxiv · Apr 23, 2020 · PreprintMicrobiology

Genome-wide transposon mutagenesis of paramyxoviruses reveals constraints on genomic plasticity

S. Ikegame, S. M. Beaty, C. Stevens, T. S. Won, A. Park, D. Sachs, P. Hong, P. A. Thibault, B. Lee

This study uses transposon mutagenesis to analyze genomic plasticity in paramyxoviruses, finding structural constraints in envelope glycoproteins and variability in genomic regions.

bioRxiv · Mar 30, 2020Microbiology