M. D. Weitzman

Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival

This study shows METTL3 is essential for survival of intestinal transit amplifying cells, maintaining growth factor signaling and KRAS expression, and its deletion leads to intestinal atrophy and death.

Viral-mediated ubiquitination impacts interactions of host proteins with viral RNA and promotes viral RNA processing

The paper identifies RNA-binding proteins as substrates of viral-mediated ubiquitination, showing that non-degradative ubiquitination enhances viral RNA processing and progeny production.

The Viral Polymerase Complex Mediates the Interaction of vRNPs with Recycling Endosomes During SeV Assembly

The paper identifies viral polymerase complex components L and C as mediators of vRNP interaction with Rab11a-marked recycling endosomes during SeV assembly.

Novel splicing and open reading frames revealed by long-read direct RNA sequencing of adenovirus transcripts

This study uses long-read RNA sequencing to identify novel adenovirus transcripts and splice variants not detectable by short-read methods.

Impaired tumor death receptor signaling drives resistance to CAR T cell therapy

This study identifies impaired death receptor signaling as a driver of resistance to CAR T cell therapy in B-cell leukemia by showing its role in tumor survival and T cell dysfunction.

Genotypic and phenotypic diversity within the neonatal HSV-2 population

This study analyzes HSV-2 isolates from neonates with different clinical outcomes, finding genomic diversity and associations between viral variants and invasive disease.

Recombination between co-infecting herpesviruses occurs where replication compartments coalesce

This study shows that herpesvirus recombination occurs when replication compartments coalesce, revealing spatial and temporal requirements for inter-genomic recombination.