Author

S. Ikegame

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Research Focus:cell type annotation· 3 Assay:flow cytometry· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:differential expression· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

B. Lee· 5 shared J. A. Acklin· 3 shared J. K. Lim· 3 shared S. Kowdle· 3 shared A. R. Patel· 2 shared C. S. Stevens· 2 shared C.-t. Hung· 2 shared I. Okamoto· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersMicrobiology

B. Lee

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis

T. Yanagihara, K. Hata, K. Matsubara, K. Kunimura, K. Suzuki, K. Tsubouchi, S. Ikegame, Y. Baba, Y. Fukui, I. Okamoto

The paper uses mass cytometry to analyze immune cell subsets in bronchoalveolar lavage fluid from patients with PCP, DI-ILD, and ICI-ILD, revealing distinct immunophenotypes associated with each condition.

bioRxiv · Feb 21, 2023Immunology

Mass cytometry identifies characteristic immune cell subsets in bronchoalveolar lavage fluid from interstitial lung diseases

K. Hata, T. Yanagihara, K. Matsubara, K. Kunimura, K. Suzuki, K. Tsubouchi, D. Eto, H. Ando, M. Uehara, S. Ikegame, Y. Baba, Y. Fukui, I. Okamoto

The paper uses mass cytometry to identify distinct immune cell subsets in BALF from ILD patients, revealing disease-specific immune signatures.

bioRxiv · Jan 12, 2023Immunology

Immunological landscape of human lymphoid explants during measles virus infection

J. A. Acklin, A. R. Patel, A. P. Kurland, S. Horiuchi, A. S. Moss, E. J. Degrace, S. Ikegame, J. Carmichael, S. Kowdle, P. Thibault, N. Imai, H. Ueno, B. Tweel, J. R. Johnson, B. R. Rosenberg, , J. K. Lim

The paper infects human lymphoid explants with measles virus and uses scRNA-Seq and flow cytometry to identify B cell preference and T cell resistance, along with ISG protein induction.

bioRxiv · Sep 12, 2022Immunology

Assessing the zoonotic potential of a novel bat morbillivirus

S. Ikegame, J. C. Carmichael, H. Wells, R. L. Furler O'Brien, J. A. Acklin, H.-P. Chiu, K. Y. Oguntuyo, R. M. Cox, A. R. Patel, S. Kowdle, C. S. Stevens, M. Eckley, S. Zhan, J. K. Lim, E. C. Veit, , B. Lee

This study identifies a novel bat morbillivirus, MBaMV, and assesses its zoonotic potential by showing it can infect human cells but is restricted by human immune responses.

bioRxiv · Sep 17, 2021 · PreprintMicrobiology

Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypes

S. Ikegame, T. Hashiguchi, C.-t. Hung, K. Dobrindt, K. Brennand, M. Takeda, B. Lee

The paper identifies hyperfusogenic measles virus F protein mutants associated with neuropathogenic phenotypes through a saturating mutagenesis screen.

bioRxiv · Dec 22, 2020Microbiology

Alpha-1-antitrypsin and its variant-dependent role in COVID-19 pathogenesis

C. S. Stevens, K. Y. Oguntuyo, S. Kowdle, A. Gowlikar, M. N. Siddiquey, J. A. Acklin, G. Haas, R. M. Schilke, M. D. Woolard, H. Zhang, L. Brambilla, S. Ikegame, C.-t. Hung, J. K. Lim, R. W. Cross, , B. Lee

This study investigates the role of alpha-1-antitrypsin in inhibiting SARS-CoV-2 entry and shows variant-dependent effects on its ability to block different viral strains.

bioRxiv · Aug 14, 2020 · PreprintMicrobiology

Genome-wide transposon mutagenesis of paramyxoviruses reveals constraints on genomic plasticity

S. Ikegame, S. M. Beaty, C. Stevens, T. S. Won, A. Park, D. Sachs, P. Hong, P. A. Thibault, B. Lee

This study uses transposon mutagenesis to analyze genomic plasticity in paramyxoviruses, finding structural constraints in envelope glycoproteins and variability in genomic regions.

bioRxiv · Mar 30, 2020Microbiology