P. Bagchi

Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50

This study investigates the effects of TIMM50 deficiency in human fibroblasts and mouse neurons, finding reduced mitochondrial function and altered potassium channel levels linked to neurological symptoms.

A Conserved Switch Controls Virulence, Sporulation, and Motility in C. difficile

This study identifies a conserved molecular switch involving Spo0E that regulates sporulation, motility, and virulence in C. difficile.

Dynamic in vivo mapping of the methylproteome using a chemoenzymatic approach

This paper develops a chemoenzymatic method to map the methylproteome in vivo, identifying known and novel methylation sites across multiple organ systems in mice.

Defining the Ligand-dependent Interactome of the Sigma 1 Receptor

This study defines the ligand-dependent interactome of the Sigma 1 Receptor using biotinylation and mass spectrometry, revealing novel interactions and functional roles in cholesterol metabolism.

Stable Flow-induced Expression of KLK10 Inhibits Endothelial Inflammation and Atherosclerosis

This study identifies KLK10 as a flow-sensitive endothelial protein that inhibits inflammation and atherosclerosis through a PAR1/2-dependent mechanism involving HTRA1 regulation.