Histone H3 E50K mutation confers oncogenic activity and supports an EMT phenotype
K. Sad, C. Y. Jones, D. V. Fawwal, E. J. Hill, K. Skinner, S. Lustenberger, R. S. Lee, S. R. Elayavalli, J. Farhi, L. D. Lemon, M. B. Fasken, A. L. Hong, S. A. Sloan, A. H. Corbett, J. M. Spangle
This paper shows that the H3E50K mutation in histone H3 promotes oncogenic activity by enhancing cell migration, invasion, and epithelial-mesenchymal transition.
bioRxiv · Oct 11, 2023 · PreprintCancer Biology