A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations
I. M. Saldana-Guerrero, L. F. Montano-Gutierrez, K. Boswell, C. Hafemeister, E. Poon, L. E. Shaw, D. Stavish, R. A. Lea, S. Wernig-Zorc, E. Bozsaky, I. S. Fetahu, P. Zoescher, U. Pötschger, M. Bernkopf, A. Wenninger-Weinzierl, , F. Halbritter
The paper uses human embryonic stem cells to show that chromosomal gains in neuroblastoma impair neural crest development and enhance MYCN-driven tumourigenesis.
bioRxiv · Nov 21, 2022Cancer Biology