M. H. Spitzer

Identification of a conserved subset of cold tumors responsive to immune checkpoint blockade

This study identifies a biomarker, {beta}Alt, that predicts immune checkpoint blockade response in cold tumors by integrating TGF{beta} signaling, DNA repair, and immune context signatures.

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

Epigenetic reprogramming shapes the cellular landscape of schwannoma

This study identifies two molecular groups in schwannomas driven by epigenetic reprogramming and shows ionizing radiation can reprogram neural crest to immune-enriched schwannomas.

A mass cytometry approach to track the evolution of T cell responses during infection and immunotherapy by paired T cell receptor repertoire and T cell differentiation state analysis

The paper develops a mass cytometry method to track T cell receptor repertoires and differentiation states during infection and immunotherapy, showing how antigen recognition influences T cell responses.

Enhancing CAR-T Cell Metabolism to Overcome Hypoxic Conditions in the Brain Tumor Microenvironment

This study shows that pretreating CAR-T cells with Metformin and Rapamycin improves their metabolic function and anti-glioma activity under hypoxic conditions in brain tumors.

Commensal myeloid crosstalk in neonatal skin regulates cutaneous type 17 inflammation

This study shows that commensal microbes in neonatal skin promote immune homeostasis by regulating monocyte accumulation and IL-17A production by T cells.

Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted by metastasis

The paper examines CD8+ T cell responses in human lymph nodes during cancer immunotherapy and finds that metastasis disrupts these responses.

T cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL-1 and TNFa Inflammation.

The paper identifies a novel mechanism of ICI resistance where T cells drive inflammatory resistance via IL-1 and TNF in tumors, with implications for therapy.

A conserved immune trajectory of recovery in hospitalized COVID-19 patients

The paper identifies a conserved immune recovery trajectory in hospitalized COVID-19 patients through longitudinal mass cytometry analysis, linking immune processes to clinical outcomes.

Transient dendritic cell activation diversifies the T cell response to acute infection

The paper shows that transient dendritic cell activation during acute infection shapes T cell fate by timing their priming and influencing whether they become effector or memory cells.

Distinct cellular immune signatures in acute Zika virus infection are associated withhigh or low persisting neutralizing antibody titers

The paper uses mass cytometry to identify immune cell signatures in acute ZIKV infection that predict high or low neutralizing antibody titers 6 months post-infection.

Type 2 innate immunity regulates hair follicle homeostasis to control Demodex pathosymbionts

This study shows that type 2 innate immunity, via ILC2s, regulates hair follicle homeostasis and maintains commensal Demodex mite colonization.

Single-cell metabolic dynamics of early activated CD8 T cells during the primary immune response to infection

The paper examines metabolic dynamics in early activated CD8 T cells during the primary immune response, identifying a transient state with maximal glycolytic and oxidative metabolic activity.

The Development, Function, and Plasticity of the Immune Macroenvironment in Cancer

The paper defines the systemic immune landscape in response to tumor development across multiple tissues and models, showing dynamic changes and plasticity in the immune macroenvironment.

Mitogen-independent cell cycle progression in B lymphocytes

This study shows B lymphocytes can undergo multiple mitosis-independent divisions after the first mitosis, driven by unique G1 phase characteristics and limited by apoptosis, with Birc5 playing an essential role.

Phospho-tuning immunity through Denisovan, modern human, and mouse TNFAIP3 gene variants

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.

Cell type-specific monoclonal antibody cross-reactivity screening in non-human primates and development of comparative immunophenotyping panels for CyTOF

The paper screens monoclonal antibodies for cross-reactivity in non-human primates and develops immunophenotyping panels for CyTOF.

A comprehensive atlas of immunological differences between humans, mice and non-human primates

The paper compares immunological differences between humans, mice, and non-human primates using CyTOF mass cytometry, identifying species-specific immune responses and correlations with viral serostatus.

Variation of immune cell responses in humans reveals sex-specific coordinated signaling across cell types

The paper profiles immune cell responses in humans to identify sex-specific signaling patterns and provides reference ranges for immune markers.

Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy

The paper presents a mass cytometry workflow for standardized immune monitoring in immunotherapy trials, identifying immune cell signatures and validating its robustness across samples and centers.