Author

L. S. Levine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Organism:human· 1

Frequent Co-Authors

M. H. Spitzer· 2 shared A. Yamamichi· 1 shared D. C. Contreras· 1 shared D. M. Marquez· 1 shared H. Okada· 1 shared I. Tenvooren· 1 shared J. C. Rathmell· 1 shared K. J. Hiam· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

M. H. Spitzer

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Author profile →

2 papers

Recent·Most cited

Enhancing CAR-T Cell Metabolism to Overcome Hypoxic Conditions in the Brain Tumor Microenvironment

R. Hatae, K. Kyewalabye, A. Yamamichi, T. Chen, S. Phyu, P. Chuntova, T. Nejo, L. S. Levine, M. H. Spitzer, H. Okada

This study shows that pretreating CAR-T cells with Metformin and Rapamycin improves their metabolic function and anti-glioma activity under hypoxic conditions in brain tumors.

bioRxiv · Nov 13, 2023Immunology

Single-cell metabolic dynamics of early activated CD8 T cells during the primary immune response to infection

L. S. Levine, K. J. Hiam, D. M. Marquez, I. Tenvooren, D. C. Contreras, J. C. Rathmell, M. H. Spitzer

The paper examines metabolic dynamics in early activated CD8 T cells during the primary immune response, identifying a transient state with maximal glycolytic and oxidative metabolic activity.

bioRxiv · Jan 21, 2020 · PreprintImmunology