P. Cordelier

Preclinical development of non-viral gene therapy for patients with advanced pancreatic cancer

This paper develops a non-viral gene therapy, CYL-02, for pancreatic cancer, demonstrating its safety, biodistribution, and therapeutic efficacy when combined with gemcitabine.

Minute virus of mice is oncolytic for pancreatic cancer cells with mesenchymal phenotype

This study shows that the minute virus of mice (MVMp) selectively targets and kills mesenchymal, basal-like pancreatic cancer cells, both in vitro and in vivo, offering a potential precision therapy for aggressive pancreatic tumors.

Cytidine deaminase regulates mitochondrial biogenesis in pancreatic cancer cells

This study shows that Cytidine deaminase (CDA) promotes mitochondrial biogenesis and oxidative phosphorylation in pancreatic cancer cells, independent of its deaminase activity, revealing new therapeutic targets.

Cytidine deaminase protects pancreatic cancer cells from replicative stress and drives resistance to DNA-targeting drugs

This study shows that Cytidine deaminase (CDA) protects pancreatic cancer cells from replication stress and contributes to resistance against DNA-targeting drugs.

Pancreatic Cancer Intrinsic PI3Kα Activity accelerates Metastasis and rewires Macrophage Component

This paper identifies PI3K pathway activation as a driver of metastatic progression in pancreatic cancer and shows that targeting PI3K can delay macro-metastatic evolution.

The antitumoral activity of TLR7 ligands is corrupted by the microenvironment of pancreatic tumors

This study shows that TLR7 ligands inhibit pancreatic cancer cell growth in vitro but promote tumor growth in immunocompetent mice due to increased tumor-promoting macrophages.