P. Flicek

Multiple adaptive solutions to face climatic constraints: novel insights in the debate over the role of convergence in local adaptation

The paper compares adaptive trajectories in sheep and goats to explore genomic convergence in local adaptation, finding few shared adaptive genes and suggesting diverse mechanisms.

A minimally morphologically destructive approach for DNA retrieval and whole genome shotgun sequencing of pinned historic Dipteran vector species

This paper develops a method to extract DNA from historic Diptera specimens with minimal morphological damage, enabling whole genome sequencing while preserving specimen integrity.

Pervasive lesion segregation shapes cancer genome evolution

This study shows that DNA lesions segregate between daughter cells, leading to chromosome-scale mutation phasing and increased genetic diversity in cancer genomes.

Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma

The paper identifies aberrant chromatin activation as a common mechanism driving the malignant phenotype in multiple myeloma.

Adaptation of proteins to the cold in Antarctic fish: A role for Methionine?

This study compares the amino acid composition of proteins in Antarctic notothenioid fish and temperate teleosts, finding a significant over-representation of methionine in notothenioid orthologues, suggesting a potential redox sensing role.