P. G. Pelicci

NF1 modulates microtubule repair and sensitivity to antibody-drug conjugates

This study shows that NF1 loss increases sensitivity to the ADC T-DM1 by modulating microtubule repair and dynamics, identifying NF1 as a predictive biomarker for ADC response.

IN VIVO ISOLATION OF A QUIESCENT MELANOMA POPULATION WITH INVASIVE PROPERTIES UNVEILS A TRANSCRIPTIONAL REPROGRAMMING DRIVEN BY THE TUMOR NICHE

The paper isolates a quiescent melanoma population in vivo, showing it has invasive properties and undergoes transcriptional reprogramming driven by the tumor niche.

INDOCYANINE GREEN IMAGING BY VITAL TISSUE SLICES SCANNING ALLOWS FOR THE ISOLATION OF INTACT LIVER MICRO-METASTASIS FOR SINGLE-CELL ANALYSIS

This study uses ICG imaging to isolate liver micro-metastases for single-cell analysis, revealing gene expression patterns predictive of breast cancer prognosis and therapeutic targets.

The breast cancer pro-metastatic phenotype requires concomitant hyper-activation of ECM remodeling and dsRNA-IFN1 signaling in rare clone cells

This study identifies that the breast cancer pro-metastatic phenotype arises from rare clones with hyper-activation of ECM remodeling and dsRNA-IFN1 signaling, and shows these genes predict metastasis progression.

Goat PRP14 (gPRP14) has xeno-antigenic properties and works as a vaccine in preclinical models of cancer.

This study characterizes gPRP14 as a tumor-specific xeno-antigen that induces anti-tumor immunity in preclinical cancer models.

High-fat diet promotes Acute Promyelocytic Leukemia through PPARδ-enhanced self-renewal of preleukemic progenitors

This study shows high-fat diet promotes Acute Promyelocytic Leukemia in mice by enhancing self-renewal of preleukemic progenitors through PPARδ activation, independent of genetic mutations.

EVALUATION OF STED SUPER-RESOLUTION IMAGE QUALITY BY IMAGE CORRELATION SPECTROSCOPY (QuICS)

The paper introduces an ICS-based algorithm to evaluate STED image quality, finding that increasing STED power improves resolution but reduces contrast, while SPLIT methods enhance resolution and contrast.

Inhibiting LSD1 suppresses coronavirus-induced inflammation but spares innate antiviral activity

The paper shows inhibiting LSD1 reduces coronavirus-induced inflammation while preserving innate antiviral activity in macrophages.

The Endless Frontier? The Recent Upsurge of R&D Productivity in Pharmaceuticals

The paper analyzes pharmaceutical R&D productivity from 1990-2017, finding a recent increase in productivity despite earlier concerns about attrition rates and trial duration.