R. Ravasio

Goat PRP14 (gPRP14) has xeno-antigenic properties and works as a vaccine in preclinical models of cancer.

This study characterizes gPRP14 as a tumor-specific xeno-antigen that induces anti-tumor immunity in preclinical cancer models.

Modeling bottlenecks, modularity, and context-dependency in behavioral control

This study uses a simple neural network model to explore how information bottlenecks affect behavioral control, showing that modular connectivity improves efficiency but increases context-dependency.

Inhibiting LSD1 suppresses coronavirus-induced inflammation but spares innate antiviral activity

The paper shows inhibiting LSD1 reduces coronavirus-induced inflammation while preserving innate antiviral activity in macrophages.

Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1, a novel oncogene in AML

This study shows that LSD1 inhibitors induce AML cell differentiation by reducing GSE1, a novel oncogene, through transcriptional activation of immune response genes.

Mechanics of allostery: contrasting the induced fit and population shift scenarios

The paper investigates allosteric conformational changes in proteins, finding that a soft elastic mode with high shear is common, and that cooperativity depends on stiffness and protein size.

Direct Coupling Analysis of Epistasis in Allosteric Materials

The paper investigates epistasis in allosteric materials using Direct Coupling Analysis, finding it predicts mutation costs but fails to capture long-range epistasis, suggesting alternative methods may be better.