S. Ke

SREBP-dependent regulation of lipid homeostasis is required for progression and growth of pancreatic ductal adenocarcinoma

This study shows that SREBP pathway inhibition slows PDAC tumor growth by disrupting lipid homeostasis, suggesting SCAP as a therapeutic target.

Rational Design of Live Biotherapeutic Products for the Prevention of Clostridioides difficile Infection

This study uses computational methods and metagenomic data to identify microbial strains that can inhibit CDI, supporting the design of live biotherapeutic products.

Optogenetic strategies for optimizing the performance of biosensors of membrane phospholipids in live cells

This paper presents optogenetic strategies to enhance phospholipid biosensors in live cells by reducing background signals and amplifying detection through light-controlled probe release and phase separation.

Association Rule Mining of the Human Gut Microbiome

This study uses association rule mining to analyze the human gut microbiome, identifying higher-order microbial relationships and showing improved disease classification.

Gut feelings: Associations of emotions and emotion regulation with the gut microbiome in women

This study investigates associations between emotions, emotion regulation, and the gut microbiome in women, finding links between emotional states and microbial diversity and pathways.

Dissecting the Role of the Human Microbiome in COVID-19 via Metagenome-assembled Genomes

This study uses metagenome-assembled genomes to analyze the human microbiome's role in COVID-19, identifying gut microbiome signatures that distinguish cases from controls and predict disease progression.

Gut Microbiota predicts Healthy Late-life Aging in Male Mice

This study shows that gut microbiota signatures from young mice can predict healthy aging in older mice under calorie restriction.

Neuropilin-1 Mediates SARS-CoV-2 Infection in Bone Marrow-derived Macrophages

This study shows SARS-CoV-2 infects bone marrow-derived macrophages via neuropilin-1, not ACE2, and affects osteoclast function.