W. Shao

SREBP-dependent regulation of lipid homeostasis is required for progression and growth of pancreatic ductal adenocarcinoma

This study shows that SREBP pathway inhibition slows PDAC tumor growth by disrupting lipid homeostasis, suggesting SCAP as a therapeutic target.

GhCPK28 negatively regulates the immune response by phosphorylating GhTIFY3b

This study identifies GhCPK28 as a negative regulator of cotton immunity against Verticillium dahliae by phosphorylating and destabilizing GhTIFY3b, enhancing resistance when silenced.

CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

This study identifies CD81+ senescent fibroblasts as key drivers of inflammation in periodontitis through the C3/C3aR1 axis and shows that senolytics and metformin can reduce inflammation and bone loss.

Regulatory divergences in dosage compensation cause hybrid male inviability in Caenorhabditis

High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function

This study shows that ZFP318 regulates mitochondrial function in memory B cells, enhancing their recallability and vaccine potency.

Reversing myeloid-derived suppressor cells mediated immunosuppression via p38α inhibition enhances immunotherapy efficacy in triple negative breast cancer

This study shows that p38α inhibition reduces immunosuppression by MDSCs and enhances immunotherapy in TNBC by decreasing CXCL1/CXCL2 expression.

Proteomic-based stratification of intermediate-risk prostate cancer patients

The paper identifies an 18-protein signature from proteomic data to stratify intermediate-risk prostate cancer patients into low- and high-risk groups for biochemical recurrence.

Spatial transcriptomics reveals a conserved segment polarity program that governs muscle patterning in Nematostella vectensis

This study uses spatial transcriptomics to identify conserved segment polarity genes in Nematostella vectensis, suggesting polarized metameric structures existed in the Cnidaria-Bilateria common ancestor.

Second-generation dual-channel visible light optical coherence tomography enables wide-field, full-range, and shot-noise limited retinal imaging

This paper introduces a second-generation dual-channel VIS-OCT system that achieves wide-field, full-range, and shot-noise limited retinal imaging with improved depth resolution and SNR.

Mesoscopic oblique plane microscopy (Meso-OPM) with a diffractive light sheet- enabling large-scale 4D cellular resolution imaging

The paper introduces Meso-OPM, a microscopy technique that enables large-scale 4D cellular resolution imaging of zebrafish larvae with improved axial resolution and field of view.

Large field-of-view incoherent volumetric imaging in living human retina by confocal oblique scanning laser ophthalmoscopy

This paper introduces CoSLO, a technique for fast, large-field-of-view incoherent 3D retinal imaging in humans, achieving >20° viewing angle in 5 seconds with 45 microns depth resolution.

Lung Epithelial Cells Can Produce Antibodies Participating In Adaptive Humoral Immune Responses

The paper shows lung epithelial cells can produce TD-Ag-specific antibodies, dependent on CD4+ T cells, challenging the notion that B cells are the sole source of such antibodies.

Phase separation of RNA-binding protein promotes polymerase engagement and transcription

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.

Integration in or Near Oncogenes Plays Only a Minor Role in Determining the in Vivo Distribution of HIV Integration Sites Before or During Suppressive Antiretroviral Therapy

The paper compares HIV integration site distributions in vivo and in vitro to assess the role of oncogene integration in viral persistence during ART.

Early Emergence and Long-Term Persistence of HIV-Infected T Cell Clones in Children

This study identifies early emergence and long-term persistence of HIV-infected T cell clones in children on antiretroviral therapy, with proviral integration in proto-oncogenes.

Wide field-of-view volumetric imaging by a mesoscopic scanning oblique plane microscopy with switchable objective lens

This paper introduces a new variant of oblique plane microscopy (OPM) that achieves a large mesoscopic field-of-view for volumetric imaging, demonstrating its application on zebrafish larvae, mouse cortex, and C. elegans.

Visible light optical coherence tomography angiography (vis-OCTA) and local microvascular retinal oximetry in human retina

This study introduces a visible light OCTA system for human retinal imaging, achieving high-speed acquisition and microvascular oximetry with sub-100 μm vessel resolution.

Volumetric fluorescence imaging in a human eye model by oblique scanning laser ophthalmoscope (oSLO): a feasibility study