Author

P. J. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:mouse· 2 Assay:multiome· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

H. Muramatsu· 2 shared N. Pardi· 2 shared Y. K. Tam· 2 shared A. A. Cohen· 1 shared A. J. Greaney· 1 shared A. Schiepers· 1 shared C. V. B. de Melo· 1 shared D. van Baarle· 1 shared

Activity by Year

2022-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersImmunology

H. Muramatsu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ESCRT recruitment to mRNA-encoded SARS-CoV-2 spike induces virus-like particles and enhanced antibody responses

M. A. Hoffmann, Z. Yang, K. E. Huey-Tubman, A. A. Cohen, P. N. Gnanapragasam, L. M. Nakatomi, K. N. Storm, W. J. Moon, P. J. Lin, P. J. Bjorkman

This study develops a vaccine technology using mRNA encoding spike-EABR to generate eVLPs, enhancing antibody and T-cell responses against SARS-CoV-2 variants.

bioRxiv · Dec 26, 2022 · PreprintImmunology

Molecular fate-mapping of serum antibodies reveals the effects of antigenic imprinting on repeated immunization

A. Schiepers, M. F. van 't Wout, A. J. Greaney, T. Zang, H. Muramatsu, P. J. Lin, Y. K. Tam, L. Mesin, T. N. Starr, P. D. Bieniasz, N. Pardi, J. D. Bloom, G. D. Victora

This study uses molecular fate-mapping to show that repeated immunization preferentially reuses initial B cell clones over recruiting new ones, with imprinting effects decreasing as antigenic distance increases.

bioRxiv · Aug 29, 2022 · PreprintImmunology

A universal influenza mRNA vaccine candidate boosts T-cell responses and reduces zoonotic influenza virus disease in ferrets

K. van de Ven, J. Lanfermeijer, H. van Dijken, H. Muramatsu, C. V. B. de Melo, S. Lenz, F. Peters, M. B. Beattie, P. J. Lin, J. A. Ferreira, J. van den Brand, D. van Baarle, N. Pardi, J. de Jonge

This study evaluates a T-cell-inducing mRNA vaccine against influenza, showing it boosts T-cell responses and reduces disease in ferrets.

bioRxiv · Aug 2, 2022Immunology

Lipid nanoparticles delivering constitutively active STING mRNA as a novel anti-cancer therapeutic approach

W. Liu, M.-G. Alameh, J. F. Yang, J. R. Xu, P. J. Lin, Y. K. Tam, D. Weissman, J. You

This study uses mRNA lipid nanoparticles to deliver an active STING mutant to treat STING-deficient cancers, enhancing immune response and inducing cancer cell death.

bioRxiv · Jan 8, 2022 · PreprintBioengineering