Author

P. J. Mullen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. S. Krall· 2 shared C. A. Lyssiotis· 2 shared C. J. Halbrook· 2 shared A. McCarthy· 1 shared A. Thambundit· 1 shared A. Viale· 1 shared B. S. Nelson· 1 shared B. Z. Stanger· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

A. S. Krall

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2 papers

Recent·Most cited

Clonal Heterogeneity Supports Mitochondrial Metabolism in Pancreatic Cancer

C. J. Halbrook, G. Thurston, A. McCarthy, B. S. Nelson, P. Sajjakulnukit, A. S. Krall, P. J. Mullen, L. Zhang, S. Batra, A. Viale, B. Z. Stanger, H. R. Cristofk, J. Zhang, M. Pasca di Magliano, C. Jorgensen, C. A. Lyssiotis

The paper identifies two metabolic subclasses in pancreatic cancer cells and shows asparagine's role in supporting proliferation under mitochondrial stress, suggesting a new therapeutic strategy.

bioRxiv · May 15, 2020 · PreprintCancer Biology

Asparagine signals mitochondrial respiration and can be targeted to impair tumour growth

A. S. Krall, P. J. Mullen, F. Surjono, M. Momcilovic, E. W. Schmid, C. J. Halbrook, A. Thambundit, S. D. Mittelman, C. A. Lyssiotis, D. B. Shackelford, S. R. Knott, H. R. Christofk

This study shows that asparagine, derived from mitochondrial respiration, supports mTORC1 activity and tumor growth, and that targeting asparagine synthesis or consumption can impair tumor growth.

bioRxiv · Mar 17, 2020 · PreprintCancer Biology