M. Momcilovic

Asparagine signals mitochondrial respiration and can be targeted to impair tumour growth

This study shows that asparagine, derived from mitochondrial respiration, supports mTORC1 activity and tumor growth, and that targeting asparagine synthesis or consumption can impair tumor growth.

Novel Kras-mutant murine models of non-small cell lung cancer possessing co-occurring oncogenic mutations and increased tumor mutational burden

This paper develops novel Kras-mutant murine NSCLC models with increased TMB and co-occurring mutations, showing enhanced anti-PD-1 efficacy but immunosuppressed TMEs in some models.