J. A. Cooper

Biophysical Mechanism of Allosteric Regulation of Actin Capping Protein

This study investigates the biophysical mechanism of allosteric regulation of actin capping protein using single-molecule FRET and MD simulations, revealing conformational changes linked to ligand binding.

N-cadherin dynamically regulates pediatric glioma cell migration in complex environments

This study shows N-cadherin dynamically regulates pediatric glioma cell migration by modulating cell-cell contacts and YAP1/TAZ signaling in different microenvironments.

RNA binding is essential for NONO condensates to modulate pre-mRNA processing in neuroblastoma

This study identifies NONO's role in neuroblastoma by showing its RNA binding is essential for forming condensates that regulate pre-mRNA processing and oncogenic gene expression.

Brain I3 Binding Protein regulates K-Ras4B membrane localization and signaling

This study identifies BRI3BP as a regulator of K-Ras4B membrane localization and function by interacting with Ras in the recycling endosomal compartment.

PolyA-modulating antisense oligonucleotides reveal opposing functions for long non-coding RNA NEAT1 isoforms in neuroblastoma

The paper develops antisense oligonucleotides to modulate NEAT1 isoform ratios in neuroblastoma, showing increased NEAT1_2 and reduced cell viability.

A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics

The paper identifies a co-regulatory circuit between Cas and BCAR3 that controls lamellipodia dynamics and cell migration through phosphorylation and ubiquitin-proteasome system interactions.

Targeting primary and metastatic uveal melanoma with a G protein inhibitor

This study evaluates the therapeutic potential of FR, a Gq/11 inhibitor, in uveal melanoma by testing its effects on tumor growth, apoptosis, and metastasis in cell lines and xenograft models.

Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium

This study identifies ameboid and mesenchymal motility mechanisms in uveal melanoma cells that facilitate transendothelial migration, with Gq/11 and BAP1 pathways playing key regulatory roles.

Comparative analysis of CPI-motif regulation of biochemical functions of actin capping protein

The paper compares the biochemical functions of CPI-motif-containing peptides from different protein families and identifies sequence variations affecting their interactions with actin capping protein.

Precise tuning of cortical contractility regulates cell shape during cytokinesis

This study shows that balancing MII paralogs fine-tunes polar cortex tension to maintain cell shape during cytokinesis.