Author

K. N. Weilbaecher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 5 Organism:human· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. M. Kirkup· 2 shared S. D. Robinson· 2 shared A. Alghamdi· 1 shared A. Andrusaite· 1 shared A. J. Dixon· 1 shared A. Joseph· 1 shared A. M. Gontarczyk· 1 shared A. M. McKee· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

B. M. Kirkup

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Author profile →

5 papers

Recent·Most cited

HTLV-1 infected T cells cause bone loss via small extracellular vesicles

N. K. Pokhrel, A. Panfil, H. Habib, S. Seeniraj, A. Joseph, D. Rauch, R. Sprung, P. E. Gilmore, Q. Zhang, R. R. Townsend, L. Yu, A. S. Yilmaz, R. Aurora, W. Park, L. Ratner, , D. J. Veis

This study shows HTLV-1 infected T cells release small extracellular vesicles that promote bone loss by stimulating osteoclasts, independent of RANKL expression.

Journal of Extracellular Vesicles · Oct 10, 2024Peer-reviewedCancer Biology

Resistance to abemaciclib is associated with increased metastatic potential and lysosomal protein deregulation in breast cancer cells

E. R. Sheidemann, D. M. Demas, C. Hou, J. Ma, W. He, K. N. Weilbaecher, A. N. Shajahan-Haq

This study shows that abemaciclib resistance in breast cancer cells is linked to increased metastatic potential and lysosomal protein deregulation, with potential therapeutic implications for combining lysosomal destabilizers.

bioRxiv · Apr 17, 2023Cancer Biology

Targeting primary and metastatic uveal melanoma with a G protein inhibitor

M. D. Onken, C. M. Makepeace, K. M. Kaltenbronn, J. Choi, L. Hernandez-Aya, K. N. Weilbaecher, K. D. Piggott, P. K. Rao, C. M. Yuede, A. J. Dixon, P. Osei-Owusu, J. A. Cooper, K. J. Blumer

This study evaluates the therapeutic potential of FR, a Gq/11 inhibitor, in uveal melanoma by testing its effects on tumor growth, apoptosis, and metastasis in cell lines and xenograft models.

bioRxiv · Jan 16, 2021 · PreprintCancer Biology

Antibiotic-induced disturbances of the gut microbiota result in accelerated breast tumour growth via a mast cell-dependent pathway

B. M. Kirkup, A. M. McKee, M. Madgwick, C. A. Price, S. A. Dreger, K. A. Makin, S. Caim, G. Le Gall, J. Pavely, C. Leclaire, M. Dalby, C. Alcon-Giner, A. Andrusaite, M. Di Modica, T. Triulzi, , S. D. Robinson

This study shows antibiotic-induced gut microbiota disturbances accelerate breast tumour growth in mice via mast cell-dependent mechanisms.

bioRxiv · Mar 7, 2020 · PreprintCancer Biology

The β3-integrin endothelial adhesome regulates microtubule dependent cell migration

S. J. Atkinson, A. M. Gontarczyk, T. S. Ellison, R. T. Johnson, B. M. Kirkup, A. Alghamdi, W. J. Fowler, B. C. Silva, J. J. Schneider, K. N. Weilbaecher, M. M. Mogensen, M. D. Bass, D. R. Edwards, S. D. Robinson

This study shows that β3-integrin regulates microtubule stability in endothelial cells through Rcc2/Anxa2 and Rac1, affecting cell migration and angiogenesis.

bioRxiv · Jun 3, 2017Cell Biology