Author

P. M. Siegel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Pause· 2 shared H. Jeong· 2 shared L. El-Houjeiri· 2 shared M. Paquette· 2 shared A. Pacis· 1 shared J. L. Estall· 1 shared J. M. J. Ramirez-Reyes· 1 shared K. Dejgaard· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

A. Pause

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Author profile →

2 papers

Recent·Most cited

AMPK-dependent phosphorylation is required for transcriptional activation of TFEB/TFE3

M. Paquette, L. El-Houjeiri, L. C. Zirden, P. Puustinen, P. Blanchette, H. Jeong, K. Dejgaard, P. M. Siegel, A. Pause

This study shows that AMPK-dependent phosphorylation of TFEB/TFE3 enhances their transcriptional activity under nutrient starvation and promotes chemoresistance in cancer.

bioRxiv · Jan 27, 2021Cancer Biology

FLCN Gene Ablation Reduces Fibrosis and Inflammation in a Diet-Induced NASH Model

M. Paquette, M. Yan, L. El-Houjeiri, M. Biondini, J. M. J. Ramirez-Reyes, A. Pacis, H. Jeong, J. L. Estall, P. M. Siegel, A. Pause

This study shows that FLCN gene ablation reduces fibrosis and inflammation in a diet-induced NASH model by enhancing autophagy and lysosomal biogenesis.

bioRxiv · Sep 10, 2020 · PreprintPathology