Author

P. N. Shah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Organism:virus· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. I. Stuart· 3 shared D. Zhou· 2 shared E. E. Fry· 2 shared H. M. E. Duyvesteyn· 2 shared J. Huo· 2 shared J. Radecke· 2 shared J. Ren· 2 shared L. Carrique· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersMicrobiology

D. I. Stuart

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Delineating organizational principles of the endogenous L-A virus by cryo-EM and computational analysis of native cell extracts

L. Schmidt, C. Tueting, F. L. Kyrilis, F. Hamdi, D. A. Semchonok, G. Hause, A. Meister, C. Ihling, P. N. Shah, M. T. Stubbs, A. Sinz, D. I. Stuart, P. L. Kastritis

The paper uses cryo-EM and computational analysis to study the structure and organization of the yeast L-A virus in native cell extracts, revealing capsid architecture and viral community dynamics.

bioRxiv · Jul 15, 2022Biochemistry

Neutralization of SARS-CoV-2 by destruction of the prefusion Spike

J. Huo, Y. Zhao, J. Ren, D. Zhou, H. M. E. Duyvesteyn, H. M. Ginn, L. Carrique, T. Malinauskas, R. R. Ruza, P. N. Shah, T. K. Tan, P. Rijal, N. Coombes, K. Bewley, J. Radecke, , D. I. Stuart

This paper identifies CR3022 as a monoclonal antibody that neutralizes SARS-CoV-2 by destroying its prefusion Spike conformation, suggesting therapeutic potential.

Cell Host & Microbe · Sep 1, 2020Peer-reviewedMicrobiology

The SARS-CoV-2 Spike harbours a lipid binding pocket which modulates stability of the prefusion trimer

L. Carrique, H. M. E. Duyvesteyn, T. Malinaukas, Y. Zhao, J. Ren, D. Zhou, T. S. Walter, J. Radecke, J. Huo, R. Ruza, P. N. Shah, E. E. Fry, D. I. Stuart

The paper identifies a lipid-binding pocket in the SARS-CoV-2 Spike that stabilizes the prefusion trimer and shields neutralizing epitopes, suggesting it as a potential drug target.

bioRxiv · Aug 13, 2020 · PreprintMicrobiology

N-Acetyl Cysteine Abrogates Silver-Induced Reactive Oxygen Species in Human Cells Without Altering Silver-Based Antimicrobial Activity

K. N. Shah, P. N. Shah, A. R. Mullen, Q. Chen, R. DeBerardinis, C. L. Cannon

This study shows N-acetyl cysteine (NAC) reduces silver-induced reactive oxygen species (ROS) in human cells without affecting silver's antimicrobial activity.

bioRxiv · Oct 3, 2019Pharmacology & Toxicology