K. N. Shah

A focal adhesion kinase-YAP signaling axis drives drug tolerant persister cells and residual disease in lung cancer

This study identifies a FAK-YAP signaling axis that drives drug-tolerant persister cells and residual disease in lung cancer, showing that inhibiting this axis improves tumor response to targeted therapies.

Antimicrobial Effects of Ibuprofen Combined with Standard of Care Antimicrobials against Cystic Fibrosis Pathogens

This study investigates the antimicrobial synergy between ibuprofen and standard-of-care antibiotics against CF pathogens, showing in vitro and in vivo efficacy against drug-resistant strains.

A tyrosine kinase protein interaction map reveals targetable EGFR network oncogenesis in lung cancer

The paper constructs a tyrosine kinase protein interaction map, revealing EGFR network oncogenesis in 19% of EGFR wild-type lung cancers, which is targetable with EGFR inhibitors.

N-Acetyl Cysteine Abrogates Silver-Induced Reactive Oxygen Species in Human Cells Without Altering Silver-Based Antimicrobial Activity

This study shows N-acetyl cysteine (NAC) reduces silver-induced reactive oxygen species (ROS) in human cells without affecting silver's antimicrobial activity.

Kinome rewiring reveals AURKA is a molecular barrier to the efficacy of PI3K/mTOR-pathway inhibitors in breast cancer

The paper identifies AURKA as a barrier to PI3K/mTOR inhibitor efficacy in breast cancer by mapping kinome dynamics and showing that AURKA inhibition synergizes with these drugs to induce apoptosis and tumor regression.