T. C. Wang

KRas, in addition to Tp53 is a driver for early carcinogenesis and a molecular target in a mouse model of invasive gastro-esophageal adenocarcinoma

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.

Nociceptive neurons interact directly with gastric cancer cells via a CGRP/Ramp1 axis to promote tumor progression

The paper identifies a CGRP/Ramp1 axis-mediated interaction between nociceptive neurons and gastric cancer cells that promotes tumor progression.

Nucleocytoplasmic transport rates are regulated by cellular processes that modulate GTP availability

The paper shows that changes in GTP availability, caused by cellular processes like migration, affect nucleocytoplasmic transport rates, impacting RNA export and protein synthesis.

Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

This study shows that p63 regulates the balance between squamous and neuroendocrine cell fates in esophageal development and cancer by modulating epigenetic mechanisms.

Loss of Grem1-articular cartilage progenitor cells causes osteoarthritis.

This study identifies Grem1-articular cartilage progenitor cells as critical for maintaining joint health, and their loss leads to osteoarthritis, with potential therapeutic targeting of FGFR3.

Immature myeloid cells are indispensable for intestinal regeneration post irradiation injury

This study shows that immature myeloid cells (IMCs) are essential for intestinal regeneration after irradiation injury, driven by microbial signals and promoting epithelial repair through PGE2 production.

Intestinal myofibroblasts regulate intestinal epithelial cell plasticity via YAP/TAZ

This study shows that intestinal myofibroblasts enhance enteroid self-renewal and survival through YAP/TAZ signaling and TGF-β, without involving Wnt.

A Holistic Analysis of the Intestinal Stem Cell Niche Network

The paper analyzes the intestinal stem cell niche by combining bulk RNA sequencing and scRNA-seq to identify a network of cell types and signals involved in ISC regulation.