Author

P. Sahgal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2

Frequent Co-Authors

A. Prosz· 3 shared S. Spisak· 3 shared V. Tisza· 3 shared Z. Szallasi· 3 shared Z. Sztupinszki· 3 shared H. Singh· 2 shared I. Csabai· 2 shared I. Paatero· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

A. Prosz

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors.

P. Sahgal, D. T. Patil, Z. Sztupinszki, V. Tisza, S. Spisak, B. Huffman, A. Prosz, H. Singh, J.-B. Lazaro, Z. Szallasi, J. M. Cleary, N. S. Sethi

The paper identifies DDR biomarkers and ploidy abnormalities in GEA that predict sensitivity to DDR inhibitors and premalignant progression.

bioRxiv · Mar 27, 2023 · PreprintCancer Biology

Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma.

A. Prosz, H. Duan, V. Tisza, P. Sahgal, S. Topka, G. T.Klus, J. Borscok, Z. Sztupinszki, T. Hanlon, M. Diossy, L. Vizkeleti, D. R. Stormoen, I. Csabai, H. Pappot, J. Vijai, , Z. Szallasi

This paper identifies NER deficiency as a targetable vulnerability in ccRCC, showing that 10% of patients may respond to irofulven based on mutational signatures and PTGR1 expression.

bioRxiv · Feb 7, 2023Cancer Biology

Diagnostic tool to identify and treat DNA repair deficient gastroesophageal adenocarcinomas

A. Prosz, P. Sahgal, C. X. Morris, Z. Sztupinszki, J. Borcsok, M. Diossy, V. Tisza, S. Spisak, O. Rusz, I. Csabai, B. M. Huffman, H. Singh, J.-B. Lazaro, M. Cecchini, J. M. Cleary, , N. S. Sethi

This study identifies HR and NER deficiencies in gastric and esophageal adenocarcinomas and shows their responsiveness to platinum chemotherapy and PARP inhibitors.

bioRxiv · Jul 14, 2022 · PreprintCancer Biology

GGA2 and RAB13 promote activity-dependent β1-integrin recycling

P. Sahgal, J. Alanko, J. Icha, I. Paatero, H. Hamidi, A. Arjonen, M. Pietila, A. Rokka, J. Ivaska

This study identifies GGA2 and RAB13 as regulators of activity-dependent β1-integrin recycling, showing their roles in maintaining integrin activity and cell migration.

bioRxiv · Feb 25, 2019Cell Biology

SORLA-driven endosomal trafficking regulates the oncogenic fitness of HER2

M. Pietila, P. Sahgal, E. Peuhu, N. Jantti, I. Paatero, O. M. Andersen, A. Padzik, M. Blomqvist, I. Saarinen, P. Bostrom, P. Taimen, J. Ivaska

This study shows SORLA regulates HER2 trafficking, affecting its oncogenic activity and response to therapy.

bioRxiv · Apr 11, 2018Cell Biology