Author

P. van Nies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:virus· 3 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. E. Cameron· 3 shared D. Dulin· 3 shared F. S. Papini· 3 shared J. J. Arnold· 3 shared M. Depken· 3 shared M. Seifert· 3 shared B. Canard· 2 shared S. C. Bera· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiophysics

C. E. Cameron

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3 papers

Recent·Most cited

The nucleotide addition cycle of the SARS-CoV-2 polymerase

S. C. Bera, M. Seifert, R. Kirchdoerfer, P. van Nies, Y. Wubulikasimu, S. Quack, F. S. Papini, J. J. Arnold, B. Canard, C. E. Cameron, M. Depken, D. Dulin

This study describes the mechanochemical behavior of the SARS-CoV-2 polymerase using magnetic tweezers, revealing three catalytic conformations and a thermal ratchet mechanism for nucleotide incorporation.

bioRxiv · Mar 27, 2021Biophysics

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single moleculeperspective

M. Seifert, S. C. Bera, P. van Nies, R. N. Kirchdoerfer, A. Shannon, T.-T.-N. Le, X. Meng, H. Xia, J. M. Wood, L. D. Harris, F. S. Papini, J. J. Arnold, S. C. Almo, T. L. Grove, P.-Y. Shi, , D. Dulin

This study investigates how nucleotide analogs like Remdesivir affect SARS-CoV-2 polymerase activity using single-molecule techniques, revealing backtracking rather than termination and evasion of ddhCTP.

bioRxiv · Aug 6, 2020 · PreprintBiophysics

Temperature controlled high-throughput magnetic tweezers show striking difference in activation energies of replicating viral RNA-dependent RNA polymerases.

M. Seifert, P. van Nies, F. S. Papini, J. J. Arnold, M. M. Poranen, C. E. Cameron, M. Depken, D. Dulin

This study uses temperature-controlled magnetic tweezers to compare replication kinetics of RdRps from three RNA viruses, finding temperature-dependent activation differences.

bioRxiv · Jan 15, 2020Biophysics