Author

L. D. Harris

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:virus· 1

Frequent Co-Authors

A. Shannon· 1 shared B. Canard· 1 shared C. E. Cameron· 1 shared D. Dulin· 1 shared E. M. M. Bulloch· 1 shared F. S. Papini· 1 shared G. B. Evans· 1 shared H. Xia· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiophysics

A. Shannon

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Inhibition of the DENV2 and ZIKV RNA polymerases by Galidesivir triphosphate measured using a continuous fluorescence assay

S. Deshpande, W. Huo, R. Shrestha, K. Sparrow, G. B. Evans, L. D. Harris, R. L. Kingston, E. M. M. Bulloch

This paper measures the inhibition of DENV2 and ZIKV RNA polymerases by Galidesivir triphosphate using a continuous fluorescence assay, finding it equipotent against both with IC50 values of 42 and 47 M.

bioRxiv · Dec 20, 2022Microbiology

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single moleculeperspective

M. Seifert, S. C. Bera, P. van Nies, R. N. Kirchdoerfer, A. Shannon, T.-T.-N. Le, X. Meng, H. Xia, J. M. Wood, L. D. Harris, F. S. Papini, J. J. Arnold, S. C. Almo, T. L. Grove, P.-Y. Shi, , D. Dulin

This study investigates how nucleotide analogs like Remdesivir affect SARS-CoV-2 polymerase activity using single-molecule techniques, revealing backtracking rather than termination and evasion of ddhCTP.

bioRxiv · Aug 6, 2020 · PreprintBiophysics